Genomics and multiomics in the age of precision medicine - Pediatric Research | Posteezy

A number of conditions have progressed through the cycle of gene discovery, pathogenesis research and development of a novel treatment, leading to clinical trials. Vemurafenib, an inhibitor of mutated BRAF, has been shown to improve overall survival and progression-free survival compared with standard therapy,15 leading to its recommendation by NICE. Increasingly, large databases of genomes across different ethnic populations, from sources including GnoMAD11 and the 100,000 genomes project,12 will improve the accuracy of interpretation.

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